{"id":1089,"date":"2017-04-09T08:01:17","date_gmt":"2017-04-09T08:01:17","guid":{"rendered":"http:\/\/dentalia.orionthemes.com\/demo-1\/?p=1089"},"modified":"2021-07-14T08:50:02","modified_gmt":"2021-07-14T04:50:02","slug":"blood-test","status":"publish","type":"post","link":"https:\/\/berlinhospitals.com\/hospital\/blood-test\/","title":{"rendered":"Scientists confirm blood test could track Alzheimer’s disease"},"content":{"rendered":"
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A long-term study supports earlier suggestions that testing the blood for levels of a certain protein could be a noninvasive way to track the progress of Alzheimer\u2019s disease.<\/h3>\n
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The protein is called neurofilament light. It spills out of damaged and dying nerve cells, into the cerebrospinal fluid and then travels from there into the bloodstream.<\/p>\n

Previous studies have already demonstrated that blood levels of neurofilament light are higher in people with diseases, such as Alzheimer\u2019s, that destroy nerve cells and tissue in the brain. However, few of these have been long-term investigations.<\/p>\n

The new study, which features in\u00a0JAMA Neurology<\/em>, suggests that measuring blood levels of neurofilament light could indicate whether drugs for treating\u00a0Alzheimer\u2019s disease\u00a0are working. As yet, there is no noninvasive way of doing this.<\/p>\n

The findings follow those of another\u00a0investigation\u00a0that showed that measuring neurofilament light in the blood could identify Alzheimer\u2019s disease 10 years or more before the emergence of symptoms such as decline in thinking and memory.<\/p>\n

However, the earlier study was limited to identifying people with a rare, inherited, early-onset form of Alzheimer\u2019s disease that usually strikes before the age of 65. The more recent research applies to sporadic Alzheimer\u2019s disease, a\u00a0far more common, late-onset type that most often strikes after the age of 65.<\/p>\n

\u201cTaken together,\u201d says lead study author Dr. Niklas Mattsson, a physician at Sk\u00e5ne University Hospital who also does research at Lund University, both in Sweden, \u201cthese studies indicate that [neurofilament light] in the blood can be used to measure damage to brain cells in various forms of Alzheimer\u2019s disease.\u201d<\/p>\n<\/div>\n

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Alzheimer\u2019s disease and brain changes<\/h4>\n

About\u00a060\u201380% of people\u00a0with\u00a0dementia\u00a0have Alzheimer\u2019s disease. The disease is complex and not easy to diagnose.<\/p>\n

The most common early symptom of Alzheimer\u2019s disease is short-term memory loss, and this, together with other symptoms of cognitive and physical deterioration that result from loss of brain cells, gradually worsens over time. Eventually, the disease can stop people from being able to live independently, as they lose the ability to relate to others and their environment.<\/p>\n

According to figures from the Alzheimer\u2019s Association, there are\u00a05.8 million people\u00a0living with Alzheimer\u2019s disease in the United States, and this number is likely to rise to just under 14 million by 2050.<\/strong><\/p>\n

There is currently no cure for Alzheimer\u2019s disease. There are some treatments that can alleviate some of the symptoms for a little time, but none, as yet, can stop the disease from progressing.<\/p>\n

The changes in the brain that accompany Alzheimer\u2019s disease begin a long time before the early symptoms start to appear. These changes include the toxic buildup of tau and beta-amyloid proteins that damage nerve cells\u2019 ability to communicate and function and eventually cause their death.<\/p>\n<\/div>\n

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Blood test \u2018cheaper and easier\u2019<\/h4>\n

For their investigation, Dr. Mattsson and his colleagues used data from the\u00a0Alzheimer\u2019s Disease Neuroimaging Initiative, a multisite study that is evaluating imaging and other biomarkers for early detection and progress-monitoring of Alzheimer\u2019s disease.<\/p>\n

The data came from records of 1,583 individuals in North America who had given regular blood samples for up to 11 years during 2005\u20132016 and whose blood analysis included measures of neurofilament light.<\/p>\n

Just over 45% of the cohort was female and the average age was 73 years. Of the individuals, 401 had no cognitive impairment, 855 had mild cognitive impairment, and 327 had dementia due to Alzheimer\u2019s disease.<\/p>\n

The researchers analyzed measures of neurofilament light protein together with other data that included: information from clinical diagnoses; markers of beta-amyloid and tau protein in cerebrospinal fluid; results from PET and\u00a0MRI\u00a0scans; and scores from thinking and memory tests.<\/p>\n

Dr. Mattsson says that they found that levels of neurofilament light protein rose \u201cover time in Alzheimer\u2019s disease\u201d and that they were \u201cin line with the accumulated brain damage\u201d that was reflected in the brain scans and cerebrospinal fluid markers.<\/strong><\/p>\n

\u201cStandard methods for indicating nerve cell damage,\u201d he explains, \u201cinvolve measuring the patient\u2019s level of certain substances, using a lumbar puncture, or examining a brain MRI.\u201d<\/p>\n

\u201cThese methods are complicated, take time, and are costly,\u201d he continues, adding that \u201cMeasuring [neurofilament light] in the blood can be cheaper and is also easier for the patient.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

A long-term study supports earlier suggestions that testing the blood for levels of a certain protein could be a noninvasive way to track the progress of Alzheimer\u2019s disease. The protein is called neurofilament light. It spills out of damaged and dying nerve cells, into the cerebrospinal fluid and then travels from there into the bloodstream.<\/p>\n","protected":false},"author":1,"featured_media":2745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oral-health"],"_links":{"self":[{"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/posts\/1089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/comments?post=1089"}],"version-history":[{"count":0,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/posts\/1089\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/media\/2745"}],"wp:attachment":[{"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/media?parent=1089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/categories?post=1089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/berlinhospitals.com\/hospital\/wp-json\/wp\/v2\/tags?post=1089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}